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Script
The proerythroblast is the first recognizable stage of the red blood cell lineage. The nucleus of the proerythroblast has one or more nucleoli. The cytoplasm is basophilic due to abundant free polyribosomes involved in hemoglobin synthesis. This stage is mitotically active. The daughter cells differentiate to form basophilic erythroblasts. The nucleus at this stage contains coarse, condensed chromatin. Nucleoli are rarely present. The cytoplasm is intensely basophilic. Cell division still occurs at the basophilic erythroblast stage. The next stage, the polychromatophilic erythroblast, shows mixed cytoplasmic staining as hemoglobin accumulates and polyribosomes decrease in number. The chromatin is increasingly condensed. Mitosis has ceased at this stage. In the orthochromatophilic erythroblast, hemoglobin staining predominates. The nucleus is extremely dense and is eccentrically located. At the completion of this stage, the nucleus is extruded along with a rim of cytoplasm. The nucleus is engulfed and digested by a macrophage. The enucleated cell is known as a reticulocyte, due to the reticular network of polyribosomes revealed by some staining methods. After one or two days, the reticulocyte is released from the bone marrow into the blood, where it develops into a mature red blood cell. Erythropoietin produced in the kidneys stimulates the proliferation and maturation of the proerythroblast and its immediate progenitors.
Subject
Proerythroblast, Hemoglobin synthesis, Basophilic erythroblasts, Cromatin condensation
Type
Animation
Format
MPEG-4
Date
02/28/2014
Contributor
Ching-Jung Chen, Abraham Kierszenbaum, Robert Levy, Jazmine Rogers, Aleksandr Vinkler
Publisher
The City College Libraries, New York, New York
Identifier
ANI006
Language
English
Rights
Red Blood Cell Development by City College of New York Digital Scholarship Services is licensed under a Creative Commons Attribution 4.0 International License.